Article

Minimally invasive 1 mm skin biopsies capture regional transcriptomic heterogeneity in vitiligo

2025-11-21

Abstract excerpt

Vitiligo is an autoimmune depigmentation disorder characterized by melanocyte loss and complex immune dysregulation. Despite therapeutic advances, variable efficacy and frequent relapse highlight the need for deeper insight into its pathophysiology. Conventional 3–5 mm skin biopsies are invasive, induce visible scars and require suturing, limiting their use in clinical and translational research. Here, we demonstr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7e162029-24d3-5c9f-b381-be3de8e2be2f
DOI: 10.1101/2025.11.21.25340665

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Minimally invasive 1 mm skin biopsies capture regional transcriptomic heterogeneity in vitiligoDOI 10.1101/2025.11.21.25340665Read

Multimodal Analyses of Stable Vitiligo Skin Identify Tissue Interactions That Control Disease PersistenceSemantic proximity Read

Vitiligo: Focus on Clinical Aspects, Immunopathogenesis, and Therapy.Semantic proximity Read

Melanocyte loss dominates the vitiligo transcriptome: a rank-based meta-analysisSemantic proximity Read

Identification and validation of RNA-binding protein SLC3A2 regulates melanocyte ferroptosis in vitiligo by integrated analysis of single-cell and bulk RNA-sequencingSemantic proximity Read

Recent advances in understanding vitiligoSemantic proximity Read

Interactome analysis of gene expression profile reveals potential novel key transcriptional regulators of skin pathology in vitiligo.Semantic proximity Read

Altered epidermal proliferation, differentiation, and lipid composition: Novel key elements in the vitiligo puzzleSemantic proximity Read

Immunometabolism in the pathogenesis of vitiligoSemantic proximity Read

Translational Research in Vitiligo.Semantic proximity Read

Multi-Omics Identifies CTSS as a Susceptibility Gene and Actionable Target That Regulates Melanocyte MHC-II Expression and Survival in Vitiligo.Semantic proximity Read

Increased melanin induces aberrant keratinocyte − melanocyte − basal − fibroblast cell communication and fibrogenesis by inducing iron overload and ferroptosis resistance in keloidsSemantic proximity Read

Single-cell RNA-seq of UVB-radiated skin reveals landscape of photoaging-related inflammation and protection by vitamin DSemantic proximity Read