Genetics of Vitiligo.

doi:10.1016/j.det.2016.11.013

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Article

Genetics of Vitiligo.

Dermatologic clinics - 1 Apr 2017

Spritz Richard A, Andersen Genevieve H L

Abstract excerpt

Vitiligo reflects simultaneous contributions of multiple genetic risk factors and environmental triggers. Genomewide association studies have discovered approximately 50 genetic loci contributing to vitiligo risk. At many vitiligo susceptibility loci, the relevant genes and DNA sequence variants are identified. Many encode proteins involved in immune regulation, several play roles in cellular apoptosis, and...

Topics

Adaptor Proteins, Signal Transducing
Apoptosis
Apoptosis Regulatory Proteins
Autoimmunity
CTLA-4 Antigen
Forkhead Transcription Factors
Genetic Predisposition to Disease
HLA-A2 Antigen
HLA-DR4 Antigen
Humans
Melanocytes
NLR Proteins
Protein Tyrosine Phosphatase, Non-Receptor Type 22
Receptor, Platelet-Derived Growth Factor alpha
Vitiligo

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Identifiers

PMID: 28317533
DOI: 10.1016/j.det.2016.11.013
PMCID: PMC5362127

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