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Article

Persistence of large mtDNA rearrangements linked to premature aging in Pol γ exonuclease-deficient mice.

Nucleic acids research - 22 Jun 2026

Wu Shilan, Lujan Scott A, Burkholder Adam B, Nissanka Nadee, Longley Matthew J, Mieczkowski Piotr, Kunkel Thomas A, Moraes Carlos T, Copeland William C

Abstract excerpt

Mitochondrial DNA (mtDNA) mutations are hallmarks of aging. mtDNA in all opisthokonts is replicated exclusively by DNA Polymerase γ (Pol γ; encoded by POLG). PolgD257A/D257A mice, lacking Pol γ exonuclease proofreading (exo-), exhibit premature aging and higher mtDNA mutation rates than Polgwt/wt (exo+) mice. Using short-read sequencing and the ultra-sensitive LostArc indel-junction detection pipeline, we...

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Aging, Premature
DNA, Mitochondrial
DNA Polymerase gamma
DNA Replication
Gene Rearrangement

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42363763
DOI: 10.1093/nar/gkag648
PMCID: PMC13309792

Genes

POLG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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