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Article

Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies.

Nature communications - 10 Nov 2015

Bratic Ana, Kauppila Timo E S, Macao Bertil, Grönke Sebastian, Siibak Triinu, Stewart James B, Baggio Francesca, Dols Jacqueline, Partridge Linda, Falkenberg Maria, Wredenberg Anna, Larsson Nils-Göran

Abstract excerpt

Replication errors are the main cause of mitochondrial DNA (mtDNA) mutations and a compelling approach to decrease mutation levels would therefore be to increase the fidelity of the catalytic subunit (POLγA) of the mtDNA polymerase. Here we genomically engineer the tamas locus, encoding fly POLγA, and introduce alleles expressing exonuclease- (exo(-)) and polymerase-deficient (pol(-)) POLγA versions. The exo(-)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26554610
DOI: 10.1038/ncomms9808
PMCID: PMC4773887

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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