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Article

Strain-Dependent Functional Variation of a Sex Specific Sox9 Enhancer.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jul 2026

Tsuchiya Iku, Tsuji-Hosokawa Atsumi, Furuhashi Suzune, Sugiyama Karin, Ogawa Yuya, Oishi Aki, Terao Miho, Takada Shuji

Abstract excerpt

In mammalian sex differentiation, Sox9 expression in undifferentiated gonads determines male development. Sox9 is regulated by multiple enhancers, of which Enh13/mXYSRa is the most critical. Disruption of the GATA4 binding site in Enh13/mXYSRa causes XY sex reversal in the C57BL/6J (B6J) strain, but not in the mixed genetic background of B6J × DBA/2. To clarify the cause of these differences, mice with the same...

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Share to Enhancer Elements, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42363649
DOI: 10.1111/gtc.70131
PMCID: PMC13380362

Genes

GATA4

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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