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Article

<i>Sox9</i> in Testis Determination

1 Dec 2005

Abstract excerpt

Sox9 is an Sry-box-containing gene that encodes a transcriptional activator. During mouse gonadogenesis, Sox9 is detected in the male gonad at 11.5 days postcoitus (dpc). At 12.5 dpc, testicular cords form, morphologically distinguishing the male gonad from the ovary. From this stage onwards, Sox9 expression is restricted to the Sertoli cell lineage and persists in the adult. Humans with heterozygous mutations in...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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Identifiers

PMID: 16467253
DOI: 10.1196/annals.1336.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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<i>Sox9</i> in Testis DeterminationPMID 16467253Read ↗

A male-specific role for <i>SOX9</i> in vertebrate sex determinationSemantic proximity Read ↗

Heterozygous deletion of Sox9 in mouse mimics the gonadal sex reversal phenotype associated with campomelic dysplasia in humans.Semantic proximity Read ↗

Diverse Regulation but Conserved Function: SOX9 in Vertebrate Sex DeterminationSemantic proximity Read ↗

Functional analysis of <i>Sox8</i> and <i>Sox9</i> during sex determination in the mouseSemantic proximity Read ↗

SOX Genes and Their Role in Disorders of Sex DevelopmentSemantic proximity Read ↗

Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone.Semantic proximity Read ↗

Turning on the male--SRY, SOX9 and sex determination in mammals.Semantic proximity Read ↗

Testicular Differentiation Occurs in Absence of R-spondin1 and Sox9 in Mouse Sex ReversalsSemantic proximity Read ↗

Sox9 induces testis development in XX transgenic mice.Semantic proximity Read ↗

<i>Sox8</i> and <i>Sox9</i> act redundantly for ovarian-to-testicular fate reprogramming in the absence of <i>R-spondin1</i> in mouse sex reversalsSemantic proximity Read ↗

SOX E genes: SOX9 and SOX8 in mammalian testis developmentSemantic proximity Read ↗

Homozygous inactivation of Sox9 causes complete XY sex reversal in mice.Semantic proximity Read ↗

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