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Article

Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone.

PLoS genetics - 1 Jan 2017

Gonen Nitzan, Quinn Alexander, O'Neill Helen C, Koopman Peter, Lovell-Badge Robin

Abstract excerpt

During mouse sex determination, transient expression of the Y-linked gene Sry up-regulates its direct target gene Sox9, via a 3.2 kb testis specific enhancer of Sox9 (TES), which includes a core 1.4 kb element, TESCO. SOX9 activity leads to differentiation of Sertoli cells, rather than granulosa cells from the bipotential supporting cell precursor lineage. Here, we present functional analysis of TES/TESCO, using...

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Topics

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Share to Enhancer Elements, Genetic
Share to Gene Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Mice, Inbred C57BL

Share to Sex Determination Processes

Share to SOX9 Transcription Factor

Share to Testis

Source

Open in PubMed Open full text

Identifiers

PMID: 28045957
DOI: 10.1371/journal.pgen.1006520
PMCID: PMC5207396

Genes

TES
SOX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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