Article
Brief report: high-throughput sequencing of IL23R reveals a low-frequency, nonsynonymous single-nucleotide polymorphism that is associated with ankylosing spondylitis in a Han Chinese population.
Arthritis and rheumatism - 1 Jul 2013
Davidson Stuart I, Jiang Lei, Cortes Adrian, Wu Xin, Glazov Evgeny A, Donskoi Marina, Zheng Yi, Danoy Patrick A, Liu Yi, Thomas Gethin P, Brown Matthew A, Xu Huji
Abstract excerpt
OBJECTIVE: Ankylosing spondylitis (AS) is a highly heritable common inflammatory arthritis that targets the spine and sacroiliac joints of the pelvis, causing pain and stiffness and leading eventually to joint fusion. Although previous studies have shown a strong association of IL23R with AS in white Europeans, similar studies in East Asian populations have shown no association with common variants of IL23R,...
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