The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia.

doi:10.1038/mp.2009.49

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Article

The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia.

Molecular psychiatry - 1 Oct 2010

Green E K, Grozeva D, Jones I, Jones L, Kirov G, Caesar S, Gordon-Smith K, Fraser C, Forty L, Russell E, Hamshere M L, Moskvina V, Nikolov I, Farmer A, McGuffin P, Holmans P A, Owen M J, O'Donovan M C, Craddock N

Abstract excerpt

Molecular genetic analysis offers opportunities to advance our understanding of the nosological relationship between psychiatric diagnostic categories in general, and the mood and psychotic disorders in particular. Strong evidence (P=7.0 × 10(-7)) of association at the polymorphism rs1006737 (within CACNA1C, the gene encoding the α-1C subunit of the L-type voltage-gated calcium channel) with the risk of bipolar...

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PMID: 19621016
DOI: 10.1038/mp.2009.49
PMCID: PMC3011210

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