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Article

Differential serum levels of CACNA1C, circadian rhythm and stress response molecules in subjects with bipolar disorder: Associations with genetic and clinical factors.

Journal of affective disorders - 15 Dec 2024

Allen Obie, Coombes Brandon J, Pazdernik Vanessa, Gisabella Barbara, Hartley Joshua, Biernacka Joanna M, Frye Mark A, Markota Matej, Pantazopoulos Harry

Abstract excerpt

BACKGROUND: Many patients with bipolar disorder (BD) do not respond to or have difficulties tolerating lithium and/or other mood stabilizing agents. There is a need for personalized treatments based on biomarkers in guiding treatment options. The calcium voltage-gated channel CACNA1C is a promising candidate for developing personalized treatments. CACNA1C is implicated in BD by genome-wide association studies and...

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Identifiers

PMID: 39233237
DOI: 10.1016/j.jad.2024.08.238
PMCID: PMC11496001

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