Article
Distinct molecular and clinical aggressiveness in very early-onset metastatic colorectal cancer: survival and genomic divergence between patients aged 30-39 versus 40-49 years.
ESMO open - 1 Jul 2026
Pretta A, Rebecchi G, Maddalena G, Marmorino F, Ziranu P, Manoni F, De Grandis M C, Carullo M, Ferrari P A, Donisi C, Randon G, Perissinotto E, Taravella A, Nasca V, Buggin F, Pretta G, Ciracì P, Bergamo F, Cremolini C, Lonardi S, Scartozzi M, Pietrantonio F
Abstract excerpt
BACKGROUND: Early-onset colorectal cancer (EOCRC) is increasing worldwide and exhibits clinical heterogeneity. Patients younger than 40 years may constitute a biologically distinct subgroup within EOCRC. We investigated whether 'very early-onset' metastatic colorectal cancer (VEOCRC, ages 30-39) exhibits specific clinical and genomic features compared with EOCRC in patients aged 40-49 and whether these...
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