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Article

A keratin 15 containing stem cell population from the hair follicle contributes to squamous papilloma development in the mouse.

Molecular carcinogenesis - 1 Oct 2013

Li Shulan, Park Heuijoon, Trempus Carol S, Gordon Derek, Liu Yaping, Cotsarelis George, Morris Rebecca J

Abstract excerpt

The multistage model of nonmelanoma skin carcinogenesis has contributed significantly to our understanding of epithelial cancer in general. We used the Krt1-15CrePR1;R26R transgenic mouse to determine the contribution of keratin 15+ cells from the hair follicle to skin tumor development by following the labeled progeny of the keratin 15 expressing cells into papillomas. We present three novel observations. First,...

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Identifiers

PMID: 22431489
DOI: 10.1002/mc.21896
PMCID: PMC3424369

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