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Article

Characterization of a vitamin D receptor knockout mouse as a model of colorectal hyperproliferation and DNA damage

1 Sept 2001

Abstract excerpt

The vitamin D receptor knockout (VDR-KO) mouse presents with a skeletal phenotype typical for complete lack of genomic 1,25-dihydroxycholecalciferol effects. Our previous data from human colorectal tissue suggest that the steroid hormone and its receptor may have protective function against tumour progression. In order to investigate the relevance of the vitamin D system for pre-malignant site-directed changes in...

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PMID: 11532865
DOI: 10.1093/carcin/22.9.1429

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