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The molecular control of meiotic double-strand break (DSB) formation and its significance in human infertility

30 Oct 2021

Abstract excerpt

Meiosis is an essential step in gametogenesis which is the key process in sexually reproducing organisms as meiotic aberrations may result in infertility. In meiosis, programmed DNA double-strand break (DSB) formation is one of the fundamental processes that are essential for maintaining homolog interactions and correcting segregation of chromosomes. Although the number and distribution of meiotic DSBs are...

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PMID: 33586697
DOI: 10.4103/aja.aja_5_21

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