Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Translational case series comparing next-generation sequencing profiles of primary breast cancer and brain metastases.

Cancer treatment and research communications - 1 Jan 2026

de Souza Carvalho Giselle, Delmonico Lucas, Alves Gilda, Ornellas Maria Helena, Rodrigues Fabiana Resende, Fernandes Priscila Valverde, Small Isabele Ávila, da Silva Jessé Lopes, Araujo Luiz Henrique Lima

Abstract excerpt

BACKGROUND: Breast cancer (BC) is a heterogeneous disease, and its molecular and immunohistochemical (IHC) profiles may change over time, particularly under therapeutic pressure. IHC discordance between primary tumors and BC brain metastases (BCBM) has been reported, yet its biological and clinical significance remains incompletely defined. Genomic profiling using next-generation sequencing (NGS) may provide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Brain Neoplasms

Share to Breast Neoplasms

Share to Erb-b2 Receptor Tyrosine Kinases

Share to PIK3CA gene

Share to High-Throughput Nucleotide Sequencing

Share to Mutation

Source

Identifiers

PMID: 42322740
DOI: 10.1016/j.ctarc.2026.101284

Genes

BRCA1
PIK3CA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Translational case series comparing next-generation sequencing profiles of primary breast cancer and brain metastases.PMID 42322740Read ↗

Discordance of PIK3CA and TP53 mutations between breast cancer brain metastases and matched primary tumors.Semantic proximity Read ↗

Discordance of PIK3CA and TP53 Mutations Between Breast Cancer Brain Metastases and Matched Primary TumorsSemantic proximity Read ↗

Gene expression profiling in a retrospective real-world cohort of breast cancer brain metastases and paired primary tumors identifies biological changes with potential therapeutic implicationsSemantic proximity Read ↗

Intrinsic Subtype Switching and Acquired ERBB2/HER2 Amplifications and Mutations in Breast Cancer Brain Metastases.Semantic proximity Read ↗

Mutational profiling of brain metastasis from breast cancer: matched pair analysis of targeted sequencing between brain metastasis and primary breast cancerSemantic proximity Read ↗

Genomic profiling using the UltraSEEK panel identifies discordancy between paired primary and breast cancer brain metastases and an association with brain metastasis-free survival.Semantic proximity Read ↗

Comprehensive molecular biomarker identification in breast cancer brain metastases.Semantic proximity Read ↗

Targeted next-generation sequencing assays using triplet samples of normal breast tissue, primary breast cancer, and recurrent/metastatic lesionsSemantic proximity Read ↗

The genomic landscape of breast cancer brain metastases: a systematic review.Semantic proximity Read ↗

Targeted next-generation sequencing assays using triplet samples of normal breast tissue, primary breast cancer, and recurrent/metastatic lesions.Semantic proximity Read ↗

Transcriptome Characterization of Matched Primary Breast and Brain Metastatic Tumors to Detect Novel Actionable TargetsSemantic proximity Read ↗

Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.