Article
Genomic profiling using the UltraSEEK panel identifies discordancy between paired primary and breast cancer brain metastases and an association with brain metastasis-free survival.
Breast cancer research and treatment - 1 Nov 2021
Giannoudis Athina, Sartori Alexander, Eastoe Lee, Zakaria Rasheed, Charlton Christopher, Hickson Nicholas, Platt-Higgins Angela, Rudland Philip S, Irwin Darryl, Jenkinson Michael D, Palmieri Carlo
Abstract excerpt
PURPOSE: Brain metastases (BM) are an increasing clinical problem. This study aimed to assess paired primary breast cancers (BC) and BM for aberrations within TP53, PIK3CA, ESR1, ERBB2 and AKT utilising the MassARRAY® UltraSEEK® technology (Agena Bioscience, San Diego, USA). METHODS: DNA isolated from 32 paired primary BCs and BMs was screened using the custom UltraSEEK® Breast Cancer Panel. Data acquisition and...
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