Article
Intrinsic Subtype Switching and Acquired ERBB2/HER2 Amplifications and Mutations in Breast Cancer Brain Metastases.
JAMA oncology - 1 May 2017
Priedigkeit Nolan, Hartmaier Ryan J, Chen Yijing, Vareslija Damir, Basudan Ahmed, Watters Rebecca J, Thomas Roby, Leone Jose P, Lucas Peter C, Bhargava Rohit, Hamilton Ronald L, Chmielecki Juliann, Puhalla Shannon L, Davidson Nancy E, Oesterreich Steffi, Brufsky Adam M, Young Leonie, Lee Adrian V
Abstract excerpt
IMPORTANCE: Patients with breast cancer (BrCa) brain metastases (BrM) have limited therapeutic options. A better understanding of molecular alterations acquired in BrM could identify clinically actionable metastatic dependencies. OBJECTIVE: To determine whether there are intrinsic subtype differences between primary tumors and matched BrM and to uncover BrM-acquired alterations that are clinically actionable....
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