Molecular characterisation of telitacicept response phenotypes in systemic lupus erythematosus: an exploratory integrated transcriptome and B-cell receptor repertoire profiling study.

Abstract excerpt

BACKGROUND: Telitacicept, a dual BAFF/APRIL inhibitor, has shown clinical efficacy in systemic lupus erythematosus (SLE), but the underlying molecular mechanisms remain incompletely understood. METHODS: We performed an integrative longitudinal study in ten patients with SLE before and after telitacicept treatment, alongside ten healthy controls. Paired transcriptome RNA sequencing and dedicated B-cell receptor...

Topics

• Humans
• Lupus Erythematosus, Systemic
• Phenotype
• Receptors, Antigen, B-Cell
• Gene Expression Profiling
• Female