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Article

Distinct gene dysregulation patterns herald precision medicine potentiality in systemic lupus erythematosus

28 Mar 2023

Abstract excerpt

OBJECTIVES: We aimed at investigating the whole-blood transcriptome, expression quantitative trait loci (eQTLs), and levels of selected serological markers in patients with SLE versus healthy controls (HC) to gain insight into pathogenesis and identify drug targets. METHODS: We analyzed differentially expressed genes (DEGs) and dysregulated gene modules in a cohort of 350 SLE patients and 497 HC from the European...

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PMID: 36996699
DOI: 10.1016/j.jaut.2023.103025

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