Article
Effective activity of cytokine-induced killer cells against autologous metastatic melanoma including cells with stemness features.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2013
Gammaitoni Loretta, Giraudo Lidia, Leuci Valeria, Todorovic Maja, Mesiano Giulia, Picciotto Franco, Pisacane Alberto, Zaccagna Alessandro, Volpe Maria Giuseppa, Gallo Susanna, Caravelli Daniela, Giacone Elena, Venesio Tiziana, Balsamo Antonella, Pignochino Ymera, Grignani Giovanni, Carnevale-Schianca Fabrizio, Aglietta Massimo, Sangiolo Dario
Abstract excerpt
PURPOSE: We investigate the unknown tumor-killing activity of cytokine-induced killer (CIK) cells against autologous metastatic melanoma and the elusive subset of putative cancer stem cells (mCSC). EXPERIMENTAL DESIGN: We developed a preclinical autologous model using same patient-generated CIK c...
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