Article
Melanoma spheroids grown under neural crest cell conditions are highly plastic migratory/invasive tumor cells endowed with immunomodulator function.
PloS one - 15 Apr 2011
Ramgolam Kiran, Lauriol Jessica, Lalou Claude, Lauden Laura, Michel Laurence, de la Grange Pierre, Khatib Abdel-Majid, Aoudjit Fawzi, Charron Dominique, Alcaide-Loridan Catherine, Al-Daccak Reem
Abstract excerpt
BACKGROUND: The aggressiveness of melanoma tumors is likely to rely on their well-recognized heterogeneity and plasticity. Melanoma comprises multi-subpopulations of cancer cells some of which may possess stem cell-like properties. Although useful, the sphere-formation assay to identify stem cell-like or tumor initiating cell subpopulations in melanoma has been challenged, and it is unclear if this model can...
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