Article
Immunomodulatory Factors Control the Fate of Melanoma Tumor Initiating Cells.
Stem cells (Dayton, Ohio) - 1 Oct 2016
Tuccitto Alessandra, Tazzari Marcella, Beretta Valeria, Rini Francesca, Miranda Claudia, Greco Angela, Santinami Mario, Patuzzo Roberto, Vergani Barbara, Villa Antonello, Manenti Giacomo, Cleris Loredana, Giardiello Daniele, Alison Malcolm, Rivoltini Licia, Castelli Chiara, Perego Michela
Abstract excerpt
Melanoma is a highly heterogeneous tumor for which recent evidence supports a model of dynamic stemness. Melanoma cells might temporally acquire tumor-initiating properties or switch from a status of tumor-initiating cells (TICs) to a more differentiated one depending on the tumor context. However, factors driving these functional changes are still unknown. We focused on the role of cyto/chemokines in shaping...
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