Impact of SLCO1B1 Gene Polymorphisms on Vadadustat Pharmacokinetics.

doi:10.1007/s13318-026-01005-1

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Impact of SLCO1B1 Gene Polymorphisms on Vadadustat Pharmacokinetics.

European journal of drug metabolism and pharmacokinetics - 1 Sept 2026

Yokoyama Satoshi, Shimada Michiko, Nakagawa Junichi, Ueno Kayo, Ishiyama Masahiro, Nakamura Norio, Tomita Hirofumi, Niioka Takenori

Abstract excerpt

BACKGROUND AND OBJECTIVE: Vadadustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor, is transported into hepatocytes via OATP1B1, which is encoded by the SLCO1B1 gene. Although interindividual variability in vadadustat pharmacokinetics (PK) has been reported, the influence of SLCO1B1 polymorphisms and the clinical relevance of coproporphyrin-I (CP-I) as a biomarker of OATP1B1 activity on...

Read the complete abstract on PubMed

Topics

Aged
Female
Humans
Male
Middle Aged
Biomarkers
Coproporphyrins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genotype

Liver-Specific Organic Anion Transporter 1

Polymorphism, Genetic

Polymorphism, Single Nucleotide

Prolyl-Hydroxylase Inhibitors

Prospective Studies

Renal Insufficiency, Chronic

Glycine

Picolinic Acids

Source

Open in PubMed

Identifiers

PMID: 42310169
DOI: 10.1007/s13318-026-01005-1

Genes

SLCO1B1
CP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of SLCO1B1 Gene Polymorphisms on Vadadustat Pharmacokinetics.PMID 42310169Read ↗

Substantially Increased Plasma Coproporphyrin-I Concentrations Associated With OATP1B1*15 Allele in Japanese General Population.Semantic proximity Read ↗

Impact of ABCC2, ABCG2 and SLCO1B1 polymorphisms on the pharmacokinetics of pitavastatin in humans.Semantic proximity Read ↗

Relationship of hemoglobin level and plasma coproporphyrin-I concentrations as an endogenous probe for phenotyping OATP1B.Semantic proximity Read ↗

Effects of the SLCO1B1*15 allele on the pharmacokinetics of pitavastatin.Semantic proximity Read ↗

Impact of Lenvatinib on OATP1B Activity in Patients with Hepatocellular CarcinomaSemantic proximity Read ↗

No significant effect of the SLCO1B1 polymorphism on the pharmacokinetics of ursodeoxycholic acid.Semantic proximity Read ↗

Effect of OATP1B1 (SLCO1B1) variant alleles on the pharmacokinetics of pitavastatin in healthy volunteers.Semantic proximity Read ↗

Structure-Based Analysis of Cefaclor Pharmacokinetic Diversity According to Human Peptide Transporter-1 Genetic Polymorphism.Semantic proximity Read ↗

Influence of CYP3A5 and ABCB1 polymorphisms on the pharmacokinetics of vincristine in adult patients receiving CHOP therapy.Semantic proximity Read ↗

Busulfan pharmacokinetics in adults – a real-world evaluation of intra-individual variabil-ity and the impact of obesity and deferasiroxSemantic proximity Read ↗

Pharmacogenetics of SLCO1B1 gene and the impact of *1b and *15 haplotypes on irinotecan disposition in Asian cancer patients.Semantic proximity Read ↗

Role of CYP24A1, VDR and GC gene polymorphisms on deferasirox pharmacokinetics and clinical outcomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.