Article
Relationship of hemoglobin level and plasma coproporphyrin-I concentrations as an endogenous probe for phenotyping OATP1B.
Clinical and translational science - 1 Jul 2021
Suzuki Yosuke, Sasamoto Yuri, Koyama Teruhide, Yoshijima Chisato, Oda Ayako, Nakatochi Masahiro, Kubo Michiaki, Momozawa Yukihide, Uehara Ritei, Ohno Keiko
Abstract excerpt
Plasma coproporphyrin-I (CP-I) concentration is used as a sensitive and selective endogenous probe for phenotyping organic anion transporting polypeptides 1B (OATP1B) activity in many studies. CP-I is produced in the process of heme synthesis, but the relationship between plasma CP-I concentrations and heme synthesis activity is unknown. In this study, we evaluated the relationship between plasma CP-I...
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