Article
Effects of the SLCO1B1*15 allele on the pharmacokinetics of pitavastatin.
Xenobiotica; the fate of foreign compounds in biological systems - 1 May 2012
Choi Chang-Ik, Lee Yun-Jeong, Lee Hye-In, Kim Bo-Hye, Kim Mi-Jeong, Jang Choon-Gon, Bae Jung-Woo, Lee Seok-Yong
Abstract excerpt
The hepatic uptake of pitavastatin is mediated by carriers, especially OATP1B1, which is encoded by the SLCO1B1 gene. Because the liver is a target organ of pitavastatin, OATP1B1 is responsible for both the pharmacological effects and clearance of pitavastatin. The effects of the SLCO1B1*15 allel...
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