Article
Combining machine learning and iterative experiments to keep pace with emerging viral variants of concern.
PLoS computational biology - 1 Jun 2026
Sheffield Thomas, Bruneau Ryan C, Won Stephen, Sale Kenneth L, Harmon Brooke, Pham Le Thanh Mai
Abstract excerpt
Modeling and predicting viral mutations before they emerge plays a crucial role in pandemic preparedness, enabling the early identification of emerging variants of concern (VOCs) and guiding timely updates to vaccines, diagnostic tests, and therapeutic strategies. However, existing machine learning models and large-scale experiments lose their predictive power as viral variants evolve further from the original...
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