Article
Predicting the mutational drivers of future SARS-CoV-2 variants of concern.
Science translational medicine - 23 Feb 2022
Maher M Cyrus, Bartha Istvan, Weaver Steven, di Iulio Julia, Ferri Elena, Soriaga Leah, Lempp Florian A, Hie Brian L, Bryson Bryan, Berger Bonnie, Robertson David L, Snell Gyorgy, Corti Davide, Virgin Herbert W, Kosakovsky Pond Sergei L, Telenti Amalio
Abstract excerpt
SARS-CoV-2 evolution threatens vaccine- and natural infection-derived immunity as well as the efficacy of therapeutic antibodies. To improve public health preparedness, we sought to predict which existing amino acid mutations in SARS-CoV-2 might contribute to future variants of concern. We tested the predictive value of features comprising epidemiology, evolution, immunology, and neural network-based protein...
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