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Article

What We Have Learned From Animal Models of Dry Eye

1 Jan 2017

Abstract excerpt

Animal models have proved valuable to investigate the pathogenesis of dry eye disease, identify therapeutic targets and the efficacy of candidate therapeutics for dry eye. Pharmacological inhibition of the lacrimal functional unit and exposure of the mouse eye to desiccating stress was found to activate innate immune pathways, promote dendritic cell maturation and initiate an adaptive T cell response to ocular...

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PMID: 28282318
DOI: 10.1097/iio.0000000000000169

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