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Article

Physiological effects of inactivation and the roles of Elovl3/ELOVL3 in maintaining ocular homeostasis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2021

Wilkerson Amber, Bhat Nita, Quoc Hai Pham Hoang, Yuksel Seher, Butovich Igor

Abstract excerpt

Recently, elongase of very long chain fatty acids-3 (ELOVL3) was demonstrated to play a pivotal role in physiology and biochemistry of the ocular surface by maintaining a proper balance in the lipid composition of meibum. The goal of this study was to further investigate the effects of ELOVL3 ablation in homozygous Elovl3-knockout mice (E3hom) in comparison with age and sex matched wild-type controls (E3wt). Slit...

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Identifiers

PMID: 33455016
DOI: 10.1096/fj.202002323R
PMCID: PMC7891900

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