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Article

Sex-differential associations of MC3R p.F45S with human metabolic profile.

Journal of neuroendocrinology - 1 Jun 2026

Kaur Tanya C, Wood Andrew R, Hawkes Gareth, Beaumont Robin N, Chundru Kartik, Weedon Michael N, Piggins Hugh D, Ellacott Kate L J

Abstract excerpt

Obesity and related metabolic disorders represent major global health challenges, highlighting the importance of understanding the central regulation of energy homeostasis. The melanocortin system is a conserved circuitry governing food intake and other neuroendocrine processes. Within this system, the melanocortin-3 receptor (MC3R) regulates energy and glucose balance, body composition, and linear growth in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Melanocortin, Type 3

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Source

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Identifiers

PMID: 42303965
DOI: 10.1111/jne.70214
PMCID: PMC13272279

Genes

MC3R

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Family of melanocortin receptor (MCR) genes in mammals-mutations, polymorphisms and phenotypic effects.Semantic proximity Read ↗

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