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Article

A conserved functional missense SNP (E100K) in sheep MC4R gene leading to functional loss and impacting the growth traits.

Journal of animal science - 8 Jan 2026

Yang Yuta, Liu Peiyao, Yan Taotao, Wang Xiangding, Zhou Qian, Li Yang, Li Ran, Zhang Qingfeng, Pan Chuanying, Lan Xianyong

Abstract excerpt

The melanocortin-4 receptor (MC4R), a key regulator of energy balance and feeding behavior, plays a critical role in sheep growth. Herein, we identified a naturally occurring conserved functional SNP (g.59480661G > A, E100K, P.Glu100Lys) in the sheep MC4R gene. Using the Kompetitive Allele Specific PCR method, we detected this mutation in 2,151 sheep from six different breeds. Association analysis revealed that...

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Share to Mutation, Missense

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Receptor, Melanocortin, Type 4

Source

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Identifiers

PMID: 41587948
DOI: 10.1093/jas/skag011
PMCID: PMC12948932

Genes

MC4R

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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