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Impact of homologous recombination repair/BReast CAncer (BRCA) gene alterations on survival in a real-world setting of metastatic prostate cancer.

BJU international - 1 Jan 2025

Wenzel Mike, Hoeh Benedikt, Koll Florestan, Humke Clara, Fassl Anne, Reis Henning, Wild Peter, Steuber Thomas, Graefen Markus, Tilki Derya, Traumann Miriam, Banek Severine, Chun Felix K H, Mandel Philipp

Abstract excerpt

OBJECTIVE: To investigate alterations of homologous recombination repair (HRR) and especially BReast CAncer 1/2 (BRCA1/2) gene on overall survival (OS). Moreover, to explore the effect of inhibition of poly(ADP-ribose)-polymerase (PARPi) as systemic therapy for metastatic castration-resistant prostate cancer (mCRPC). PATIENTS AND METHODS: Of all HRR-screened patients with metastatic prostate cancer, baseline...

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Identifiers

PMID: 38982928
DOI: 10.1111/bju.16462
PMCID: PMC11628939

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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