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Homologous Recombination Repair Deficiency in Metastatic Prostate Cancer: New Therapeutic Opportunities

24 Apr 2024

Abstract excerpt

More than 20% of metastatic prostate cancer carries genomic defects involving DNA damage repair pathways, mainly in homologous recombination repair-related genes. The recent approval of olaparib has paved the way to precision medicine for the treatment of metastatic prostate cancer with PARP inhibitors in this subset of patients, especially in the case of BRCA1 or BRCA2 pathogenic/likely pathogenic variants. In...

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PMID: 38731844
DOI: 10.3390/ijms25094624

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