Genetically predicted urinary sodium excretion and urolithiasis risk: a two-sample mendelian randomization study.

Abstract excerpt

BACKGROUND: High sodium intake has been linked to kidney stone formation in many observational studies, but these findings may be influenced by dietary habits and fluid intake. Whether urinary sodium itself plays a causal role in urolithiasis remains unclear. METHODS: We performed a two-sample Mendelian randomization analysis to examine the association between urinary sodium excretion and urolithiasis risk....

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