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Genetic correlation and mendelian randomization reveal the impact of sleep traits on urolithiasis risk.

Scientific reports - 20 Dec 2024

Yan Mo, Zhang Zhe-Xin, Hu Jia-Xin, Wang Kai-Bin, Liu Cheng-Yi

Abstract excerpt

Urolithiasis is a common and recurrent condition in the urological spectrum. Despite various proposed mechanisms, the causal relationship between sleep traits and the risk of urolithiasis remains unclear. We used publicly available genome-wide association study (GWAS) summary data from the UK Biobank and FinnGen to perform a two-sample Mendelian randomization (MR) analysis and genetic correlation analysis,...

Topics

Humans
Mendelian Randomization Analysis
Urolithiasis
Sleep
Genome-Wide Association Study
Polymorphism, Single Nucleotide
Risk Factors
Genetic Predisposition to Disease
Sleep Initiation and Maintenance Disorders
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

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Open in PubMed Open full text

Identifiers

PMID: 39706855
DOI: 10.1038/s41598-024-82031-4
PMCID: PMC11662003

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