Genetic evidence for potential causal associations between gut microbiota and site-specific urolithiasis risk: a two-sample mendelian randomization study.

Abstract excerpt

Urolithiasis is a common and recurrent condition with substantial clinical burden. Although observational studies have linked the gut microbiome to stone formation, causal inference is limited by confounding and reverse causation. We applied two-sample Mendelian randomization (MR), a genetic epidemiological approach that uses germline genetic variants as instrumental variables to minimize confounding and reverse...

Topics

• Humans
• Mendelian Randomization Analysis
• Urolithiasis
• Gastrointestinal Microbiome
• Genome-Wide Association Study
• Polymorphism, Single Nucleotide