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Article

Causal effect of urinary sodium-to-creatinine ratio on gastrointestinal diseases: A two-sample Mendelian randomization study.

Medicine - 15 May 2026

Jiang Yan, Zhang Zhang, Ding Yining, Xu Shuling, Chen Rumeng, Zheng Zhiwei, Bao Meihua, He Binsheng, Li Sen

Abstract excerpt

Given the epidemiological evidence suggesting an association between sodium intake and various gastrointestinal (GI) disorders, this study aimed to investigate the causal effect of genetically predicted urinary sodium-to-creatinine ratio (UNaUCr), a proxy for sodium intake, on GI diseases. Employing a Mendelian Randomization (MR) approach, genetic variants closely associated with UNaUCr were identified by...

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Identifiers

PMID: 42152304
DOI: 10.1097/MD.0000000000048692
PMCID: PMC13183035

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