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Article

Phenotypic response surfaces in pharmacology: Mechanistic and translational perspectives on optimizing drug combination therapies.

Biochemical pharmacology - 1 Sept 2026

Amin Adnan, Khan Khalil Atif Ali, Akhtar Muhammad Saeed, Ali Sajid, Zaman Wajid

Abstract excerpt

Combination drug therapies are central to the treatment of diseases with multifactorial etiology, including cancer, infectious diseases, and autoimmune disorders. Despite their widespread use, optimizing drug combinations remains challenging because of complex pharmacokinetic and pharmacodynamic interactions and substantial inter-patient variability. Phenotypic Response Surfaces (PRS) have emerged as a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42297219
DOI: 10.1016/j.bcp.2026.118168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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