Article
Novel computational approaches to polypharmacology as a means to define responses to individual drugs.
Annual review of pharmacology and toxicology - 1 Jan 2012
Xie Lei, Xie Li, Kinnings Sarah L, Bourne Philip E
Abstract excerpt
Polypharmacology, which focuses on designing therapeutics to target multiple receptors, has emerged as a new paradigm in drug discovery. Polypharmacological effects are an attribute of most, if not all, drug molecules. The efficacy and toxicity of drugs, whether designed as single- or multitarget therapeutics, result from complex interactions between pharmacodynamic, pharmacokinetic, genetic, epigenetic, and...
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