Article
Toward generalizable prediction of cancer signal using a cell-free DNA language model.
Cell reports. Medicine - 21 Jul 2026
Xu Yang, Bao Hua, Huang Daxin, Zhang Kun, Zhu Junfei, Yang Liu, Fu Shengling, Chang Zhili, Zhang Jinfeng, Chang Shuang, Zhu Baihan, Wu Shuyu, Yang Shanshan, Wu Xue, Shao Yang
Abstract excerpt
Cell-free DNA can be used for early cancer detection, minimal residual disease monitoring, and post-treatment risk stratification. However, current assays are often designed for a single purpose and rely on deep or broad sequencing panels that capture only a small fraction of tumor-derived signals, limiting transferability, increasing cost, and reducing scalability. Fragmentia-AI is an artificial intelligence...
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