Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Role of the Surgical Pathologist in the Recognition of Hereditary SDH-Deficient Tumor Syndromes.

Advances in anatomic pathology - 1 Jul 2026

Juhlin C Christofer, Mete Ozgur

Abstract excerpt

Succinate dehydrogenase (SDH)-deficient tumors form an expanding, clinically important group of neoplasms driven by disruption of mitochondrial complex II through germline or somatic alterations in SDHA-D or SDHAF2 , or by epigenetic silencing within the pathway. For the surgical pathologist, recognition of SDH deficiency has immediate implications for risk stratification, treatment selection, and identification...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carney Complex
Share to Electron Transport Complex II
Share to Gastrointestinal Stromal Tumors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leiomyosarcoma

Share to Neoplastic Syndromes, Hereditary

Share to Paraganglioma

Share to Pheochromocytoma

Share to Succinate Dehydrogenase

Source

Identifiers

PMID: 42281449
DOI: 10.1097/PAP.0000000000000541

Genes

SDHA
SDHAF2
SDHB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Role of the Surgical Pathologist in the Recognition of Hereditary SDH-Deficient Tumor Syndromes.PMID 42281449Read ↗

Succinate Dehydrogenase-deficient TumorsSemantic proximity Read ↗

Succinate dehydrogenase (SDH) and mitochondrial driven neoplasia.Semantic proximity Read ↗

Succinate dehydrogenase (SDH)‐deficient neoplasiaSemantic proximity Read ↗

Pathology and genetics of phaeochromocytoma and paragangliomaSemantic proximity Read ↗

Back to Biochemistry: Evaluation for and Prognostic Significance of SDH Mutations in Paragangliomas and Pheochromocytomas.Semantic proximity Read ↗

Back to Biochemistry: Evaluation for and Prognostic Significance of SDH Mutations in Paragangliomas and Pheochromocytomas.Semantic proximity Read ↗

Succinate Dehydrogenase (SDH)-Deficient Pancreatic Neuroendocrine Tumor Expands the SDH-Related Tumor Spectrum.Semantic proximity Read ↗

A Review of Genomic Testing and SDH ‐ Deficiency in Gastrointestinal Stromal Tumors: Getting to the GISTSemantic proximity Read ↗

The Changing Paradigm of Head and Neck Paragangliomas: What Every Otolaryngologist Needs to Know.Semantic proximity Read ↗

Carney Triad, Carney-Stratakis Syndrome, 3PAS and Other Tumors Due to SDH DeficiencySemantic proximity Read ↗

[General anatomic and histopathological diagnostic aspects of hereditary tumor syndromes : The role of pathology].Semantic proximity Read ↗

A review of the tumour spectrum of germline succinate dehydrogenase gene mutations: Beyond phaeochromocytoma and paraganglioma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.