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Article

A review of the tumour spectrum of germline succinate dehydrogenase gene mutations: Beyond phaeochromocytoma and paraganglioma.

Clinical endocrinology - 1 Nov 2020

MacFarlane James, Seong Keat Cheah, Bisambar Chad, Madhu Basetti, Allinson Kieren, Marker Alison, Warren Anne, Park Soo-Mi, Giger Olivier, Challis Benjamin G, Maher Eamonn R, Casey Ruth T

Abstract excerpt

The citric acid cycle, also known as the Krebs cycle, plays an integral role in cellular metabolism and aerobic respiration. Mutations in genes encoding the citric acid cycle enzymes succinate dehydrogenase, fumarate hydratase and malate dehydrogenase all predispose to hereditary tumour syndromes. The succinate dehydrogenase enzyme complex (SDH) couples the oxidation of succinate to fumarate in the citric acid...

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PMID: 32686200
DOI: 10.1111/cen.14289

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