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Article

Succinate dehydrogenase (SDH)‐deficient neoplasia

14 Dec 2017

Abstract excerpt

The succinate dehydrogenase (SDH) complex is a key respiratory enzyme composed of four subunits: SDHA, SDHB, SDHC and SDHD. Remarkably, immunohistochemistry for SDHB becomes negative whenever there is bi-alleic inactivation of any component of SDH, which is very rare in the absence of syndromic disease. Therefore, loss of SDHB immunohistochemistry serves as a marker of syndromic disease, usually germline mutation...

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PMID: 29239034
DOI: 10.1111/his.13277

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