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Succinate Dehydrogenase-deficient Tumors

13 Jun 2012

Abstract excerpt

Just over 10 years ago, germline mutations in SDHD, a gene that encodes 1 of the 4 proteins of the succinate dehydrogenase (SDH) complex, were reported in a subset of patients with hereditary paraganglioma-pheochromocytoma syndrome. Since that time, rapid discoveries have been made in this area. It is now recognized that all of the SDH genes are involved in the tumorigenesis of not only...

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PMID: 22692282
DOI: 10.1097/pap.0b013e31825c6bc6

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