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Article

Evaluation of HIV-1 integrase variability by combining computational and probabilistic approaches.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jul 2022

Vergni Davide, Santoni Daniele, Bouba Yagai, Lemme Saverio, Fabeni Lavinia, Carioti Luca, Bertoli Ada, Gennari William, Forbici Federica, Perno Carlo Federico, Gagliardini Roberta, Ceccherini-Silberstein Francesca, Santoro Maria Mercedes

Abstract excerpt

This study aimed at updating previous data on HIV-1 integrase variability, by using effective bioinformatics methods combining different statistical instruments from simple entropy and mutation rate to more specific approaches such as Hellinger distance. A total of 2133 HIV-1 integrase sequences were analyzed in: i) 1460 samples from drug-naïve [DN] individuals; ii) 386 samples from drug-experienced but INI-naïve...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35513162
DOI: 10.1016/j.meegid.2022.105294

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