Article
An entropy-based framework for genomic variability analysis: A South American case study of human papillomavirus.
PloS one - 1 Jan 2026
López Leal Alan, Valdés-Muñoz Elizabeth, Faundez-Acuña Jorge Y, Rojas-Pérez Víctor, D Afonseca Vivían, Silva-Aravena Fabián
Abstract excerpt
The genetic diversity of Human Papillomavirus (HPV) poses challenges for molecular detection and genotyping, particularly in regions with distinctive circulating variants such as South America. This study aimed to quantitatively characterize HPV genomic variability using Shannon entropy (H) and to establish a reproducible framework for systematic variability assessment. Positional entropy was calculated across...
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