The anti-inflammatory efficacy of melanocortin drugs is influenced by genetic variation at MC1R.

doi:10.1038/s41598-026-57399-0

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Article

The anti-inflammatory efficacy of melanocortin drugs is influenced by genetic variation at MC1R.

Scientific reports - 11 Jun 2026

Khodeneva Natalya, Davan-Wetton Camilla S A, Jonassen Thomas E N, Perretti Mauro, Montero-Melendez Trinidad

Abstract excerpt

The melanocortin 1 receptor (MC1R) is a pro-resolving anti-inflammatory target under clinical development for scleroderma, arthritis, light intolerance or melanoma prevention. Genetic diversity at MC1R is high in certain populations, with some variants associated with loss-of function (LoF) resulting in red hair and poor tanning response. However, how these variants influence the anti-inflammatory efficacy of...

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PMID: 42277217
DOI: 10.1038/s41598-026-57399-0
PMCID: PMC13507197

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MC1R

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