Article
Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms.
Human molecular genetics - 15 May 2016
Horikoshi Momoko, Pasquali Lorenzo, Wiltshire Steven, Huyghe Jeroen R, Mahajan Anubha, Asimit Jennifer L, Ferreira Teresa, Locke Adam E, Robertson Neil R, Wang Xu, Sim Xueling, Fujita Hayato, Hara Kazuo, Young Robin, Zhang Weihua, Choi Sungkyoung, Chen Han, Kaur Ismeet, Takeuchi Fumihiko, Fontanillas Pierre, Thuillier Dorothée, Yengo Loic, Below Jennifer E, Tam Claudia H T, Wu Ying, Abecasis Gonçalo, Altshuler David, Bell Graeme I, Blangero John, Burtt Noél P, Duggirala Ravindranath, Florez Jose C, Hanis Craig L, Seielstad Mark, Atzmon Gil, Chan Juliana C N, Ma Ronald C W, Froguel Philippe, Wilson James G, Bharadwaj Dwaipayan, Dupuis Josee, Meigs James B, Cho Yoon Shin, Park Taesung, Kooner Jaspal S, Chambers John C, Saleheen Danish, Kadowaki Takashi, Tai E Shyong, Mohlke Karen L, Cox Nancy J, Ferrer Jorge, Zeggini Eleftheria, Kato Norihiro, Teo Yik Ying, Boehnke Michael, McCarthy Mark I, Morris Andrew P
Abstract excerpt
To gain insight into potential regulatory mechanisms through which the effects of variants at four established type 2 diabetes (T2D) susceptibility loci (CDKAL1, CDKN2A-B, IGF2BP2 and KCNQ1) are mediated, we undertook transancestral fine-mapping in 22 086 cases and 42 539 controls of East Asian, European, South Asian, African American and Mexican American descent. Through high-density imputation and conditional...
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