Clinical, Dietary, Lifestyle and Genetic Factors Associated With Age at Onset of Esophageal Adenocarcinoma.

doi:10.1002/ueg2.70236

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Clinical, Dietary, Lifestyle and Genetic Factors Associated With Age at Onset of Esophageal Adenocarcinoma.

United European gastroenterology journal - 1 Jun 2026

Koch Vera, Gockel Ines, Reingruber Julian, Kreuser Nicole, Bigge Jessica, Venerito Marino, Alakus Hakan, May Andrea, Gerges Christian, Thieme René, Heider Dominik, Hillmer Axel M, Ebigbo Alanna, Bruns Christiane J, Lang Hauke, Messmann Helmut, Rösch Thomas, Wissniowski Thaddäus T, Müller Michaela, Denzer Ulrike W, Nöthen Markus M, Vieth Michael, Thrift Aaron P, Maj Carlo, Schumacher Johannes

Abstract excerpt

BACKGROUND: Esophageal adenocarcinoma (EAC) represents one of the most increasing malignancies in Western countries. The disease is multifactorial, involving modifiable risk factors and genetic susceptibility variants. These variants can be aggregated to a polygenic risk score (PRS) that reflects individual genetic risk. Investigation of the effects of lifestyle factors, PRS, and co-medication on EAC age at onset...

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PMID: 42272320
DOI: 10.1002/ueg2.70236
PMCID: PMC13254487

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