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Article

NGS and emerging molecular scenarios in chronic myeloproliferative neoplasms: a case of double mutated polycythemia vera.

Annals of hematology - 11 Jun 2026

Cerchiara Elisabetta, Cristiano Antonio, Vozella Federico, Gambaro Francesco Luigi, Iovene Francesca Romana, Barsotti Rachele Maria, Ristori Maria Vittoria, De Cesaris Marina, Rigacci Luigi, Angeletti Silvia

Abstract excerpt

Myeloproliferative neoplasms (MPNs) are clonal hematopoietic disorders driven by mutually exclusive JAK2, CALR, MPL mutations. NGS has revealed rare cases with coexisting driver mutations, challenging classical diagnostic paradigms, highlighting clonal complexity. We describe a 71-year-old man with JAK2-positive polycythemia vera (PV) whose hematologic parameters remained suboptimally controlled under...

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Source

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Identifiers

PMID: 42271111
DOI: 10.1007/s00277-026-07099-6
PMCID: PMC13478021

Genes

JAK2
CALR
DNMT3A
MPL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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